NMR ANALYSIS OF THE DYNAMIC EXCHANGE OF THE NS2B COFACTOR BETWEEN OPEN AND CLOSED CONFORMATIONS OF THE WEST NILE VIRUS NS2B-NS3 PROTEASE.

NMR analysis of the dynamic exchange of the NS2B cofactor between open and closed conformations of the West Nile virus NS2B-NS3 protease.

BACKGROUND: The two-component NS2B-NS3 proteases of West Nile and dengue viruses are essential for viral replication and established targets for drug development.In all crystal structures of the proteases to date, the NS2B cofactor is located far from the substrate binding site (open conformation) in the absence of inhibitor and lining the substrat

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Classification of acute myeloid leukemia subtypes M1, M2 and M3 using active contour without edge segmentation and momentum backpropagation artificial neural network

Acute Myeloid Leukemia (AML) is a type of cancer which attacks white blood cells from myeloid.AML has eight subtypes, namely: M0, M1, M2, M3, M4, M5, M6, and M7.AML subtypes M1, M2 and M3 are affected by the same type of cells, myeloblast, making it needs more detailed analysis to distinguish.To overcome these obstacles, this research is applying d

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PENERAPAN METODE PEMBELAJARAN INKUIRI UNTUK MENINGKATKAN KEAKTIFAN BELAJAR DAN HASIL BELAJAR MATA DIKLAT SISTEM INJEKSI BAHAN BAKAR BENSIN PADA SISWA KELAS XII TKR SMK MUHAMMADIYAH CANGKRINGAN SLEMAN YOGYAKARTA

The purpose of this study (1) to founds progress learning active, couse system injection fuel gasoline for students vocational high scool Muhammadiyah Cangkringan Sleman Yogyakarta for students class XII withmethod inkuiri learning strategy (2) for increase the results of study coorse system injection fuel gasoline for students class XII techniave

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Synergistic Effect Between Taurine-Induced Silver Ion and Itraconazole Against Azole-Resistant Candida Species and Candida auris

AIM: To combat the rising threat of azole-resistant Candida species and the global concern of Candida auris, exploring combination therapies with existing antimicrobial agents is critical.BACKGROUND: Azoles are the first-line choice for treating candidiasis within a limited antifungal option.However, azole-resistant Candida species have increased r

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